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Article

TP53 isoform dysregulation in pediatric B-ALL: identifying markers of favorable prognosis and relapse-associated dynamic.

Molecular biology reports - 23 Jun 2026

Kaur Parminder, Hasib T K, Kaur Sargeet, Sharun, Bhatia Prateek, Trehan Amita, Sachdeva Man Updesh Singh, Sreedharanunni Sreejesh, Singh Minu

Abstract excerpt

BACKGROUND: TP53 isoforms produced by alternate splicing and promoter usage are shown to play a role in pathogenesis, chemoresistance and relapse in various cancers. Our present study focused on analyzing the expression of different TP53 isoforms in pediatric B cell acute lymphoblastic leukemia (B-ALL). METHODS: We performed the transcriptomic analysis of TP53 isoforms expression in publicly available datasets...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42334648
DOI: 10.1007/s11033-026-12147-5

Genes

TP53
ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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