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Article

Impact of TP53 gene variants on prognosis and survival of childhood acute lymphoblastic leukemia.

Scandinavian journal of clinical and laboratory investigation - 1 May 2023

Firtina Sinem, Erbilgin Yucel, Hatirnaz Ng Ozden, Karaman Serap, Karakas Zeynep, Celkan Tulin Tiraje, Gelen Sema Aylan, Yildirmak Yildiz, Ozbek Ugur, Sayitoglu Muge

Abstract excerpt

The tumor suppressor protein 53 (TP53) gene is one of the most studied genes in cancer. Although TP53 variants are rare events in acute leukemia, recent observations showed that relapse samples might harbor TP53 variants. Here, we aimed to determine TP53 variants (hotspot region, exon 4-11) in childhood acute lymphoblastic leukemia (B and T-ALL) patients (n = 94) including diagnostic-relapse pairs (n = 15) by...

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Share to Genes, p53
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 37029683
DOI: 10.1080/00365513.2023.2195682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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