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Article

Forward genetic screen of human transposase genomic rearrangements.

BMC genomics - 4 Aug 2016

Henssen Anton G, Jiang Eileen, Zhuang Jiali, Pinello Luca, Socci Nicholas D, Koche Richard, Gonen Mithat, Villasante Camila M, Armstrong Scott A, Bauer Daniel E, Weng Zhiping, Kentsis Alex

Abstract excerpt

BACKGROUND: Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates. RESULTS: To enable functional analysis of human transposase-derived genes, we combined forward chemical genetic hypoxanthine-guanine phosphoribosyltransferase 1 (HPRT1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27491780
DOI: 10.1186/s12864-016-2877-x
PMCID: PMC4973553

Genes

HPRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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