Large-scale mutational analysis uncovers molecular mechanisms governing dual RNA functions in transposons.

doi:10.1093/nar/gkag815

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Large-scale mutational analysis uncovers molecular mechanisms governing dual RNA functions in transposons.

Nucleic acids research - 24 Aug 2026

Mortman Edan E, Sternberg Samuel H

Abstract excerpt

Transposons are among the most abundant mobile genetic elements in nature. IStrons are a unique class of transposons, encoding a transposase for transposon mobility, an RNA-guided nuclease for maintenance, and a self-splicing group I intron for element removal from host mRNA. However, it is unclear how a single polynucleotide sequence balances these distinct biochemical functions. Here, we employed pooled library...

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DNA Cleavage
DNA Transposable Elements
GC gene
Introns
Mutation
RNA Splicing
Transposases

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PMID: 42660554
DOI: 10.1093/nar/gkag815
PMCID: PMC13521648

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