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Article

Transposon clusters as substrates for aberrant splice-site activation.

RNA biology - 1 Mar 2021

Alvarez Maria Elena Vilar, Chivers Martin, Borovska Ivana, Monger Steven, Giannoulatou Eleni, Kralovicova Jana, Vorechovsky Igor

Abstract excerpt

Transposed elements (TEs) have dramatically shaped evolution of the exon-intron structure and significantly contributed to morbidity, but how recent TE invasions into older TEs cooperate in generating new coding sequences is poorly understood. Employing an updated repository of new exon-intron boundaries induced by pathogenic mutations, termed DBASS, here we identify novel TE clusters that facilitated exon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32965162
DOI: 10.1080/15476286.2020.1805909
PMCID: PMC7951965

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