Article

Pharmacokinetic considerations for optimizing inhaled spray-dried pyrazinoic acid formulations

2023-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), remains a leading cause of death with 1.6 million deaths worldwide reported in 2021. Oral pyrazinamide (PZA) is an integral part of anti-TB regimens, but its prolonged use has the potential to drive development of PZA resistant Mtb . PZA is converted to the active moiety pyrazinoic acid (POA) by the Mtb pyrazinamidase encoded b...

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Literature Corpus work: 7986f3b7-e1ba-5516-917d-0c4fbfb5f729
DOI: 10.1101/2023.04.01.534965

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