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Article

Establishing a framework for human dose prediction in anti-tuberculosis drug development

2026-05-28

Abstract excerpt

<h4>Rationale</h4> Efficacious dose selection for anti-tuberculosis drugs has traditionally relied on achieving plasma exposures above the minimum inhibitory concentration, but this approach has not consistently aligned with clinical outcomes. <h4>Objectives</h4> We sought to identify early pharmacokinetic-pharmacodynamic targets most predictive of clinical efficacious dose. <h4>Methods</h4> We conducted a back...

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Literature Corpus work
5f4c6d92-73d0-5be6-b474-aa790e42c736
DOI
10.64898/2026.05.26.26354063
Open publication

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Establishing a framework for human dose prediction in anti-tuberculosis drug developmentDOI 10.64898/2026.05.26.26354063
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