Article

Lesion penetration predicts tuberculosis regimen success: a validated translational tool for de-risking late-stage drug development

2025-06-25

Abstract excerpt

<title>Abstract</title> Anti-tuberculosis (TB) drugs must reach the disease site to be effective, but the complex TB pathology limits drug distribution and efficacy, as bacteria in the necrotic center of lung cavities are difficult to access and kill. Our study generated the most comprehensive database of site-of-disease distribution for 24 drugs in a rabbit model of cavitary TB. We validated a lung lesion p...

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Literature Corpus work: fe1251a0-8aa1-5330-8af1-2f8e1a6c7a42
DOI: 10.21203/rs.3.rs-6890010/v1

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