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<scp>TB</scp> drug development: immunology at the table

20 Feb 2015

Abstract excerpt

Our understanding of the host-pathogen relationship in tuberculosis (TB) can help guide drug discovery in at least two ways. First, the recognition that host immunopathology affects lesional TB drug distribution means that pharmacokinetic evaluation of drug candidates needs to move beyond measurements of drug levels in blood, whole lungs, or alveolar epithelial lining fluid to include measurements in specific...

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PMID: 25703568
DOI: 10.1111/imr.12275

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