Article

APOE4 increases energy metabolism in APOE-isogenic iPSC-derived neurons

2024-06-03

Abstract excerpt

The apolipoprotein E4 (APOE4) allele represents the major genetic risk factor for Alzheimer’s disease (AD). In contrast, APOE2 is known to lower the AD risk while APOE3 is defined as risk neutral. APOE plays a prominent role in the bioenergetic homeostasis of the brain, and early-stage metabolic changes have been detected in brains of AD patients. Although APOE is primarily expressed by astrocytes in the brain, ne...

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Literature Corpus work: ee82794e-38ed-5dd4-b80a-e6ae9ec8cb01
DOI: 10.1101/2024.06.03.597106

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