Article

Apolipoprotein E4 modulates astrocyte neuronal support functions in the presence of amyloid-β

2022-09-30

Abstract excerpt

Apolipoprotein E (APOE) is a lipid transporter produced predominantly by astrocytes in the brain. The ε4 variant of APOE (APOE4) is the strongest and most common genetic risk factor for Alzheimer’s disease (AD). Although the molecular mechanisms of this increased risk are unclear, APOE4 is known to alter immune signaling and lipid and glucose metabolism. Astrocytes provide various forms of support to neurons, incl...

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Literature Corpus work: 95e05cb0-34fe-59df-866e-756026e1851f
DOI: 10.1101/2022.09.29.510145

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