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Article

An accurate genetic colocalization method for the HLA locus

2024-11-05

Abstract excerpt

Genetic colocalization analyses are frequently conducted to determine if causal signals at a genetic locus are shared between two phenotypes. However, colocalization is rarely undertaken at the HLA locus, due to its complex linkage disequilibrium (LD) and high polymorphism density. This lack of genetic causal inference method limits our ability to translate HLA associations into therapeutic targets. Here we presen...

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Literature Corpus work
7917de08-6d56-58d8-b3f7-054b79586fbd
DOI
10.1101/2024.11.05.24316783
Open publication

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An accurate genetic colocalization method for the HLA locusDOI 10.1101/2024.11.05.24316783
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