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Article

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls.

Nature genetics - 1 Jul 2015

Fortune Mary D, Guo Hui, Burren Oliver, Schofield Ellen, Walker Neil M, Ban Maria, Sawcer Stephen J, Bowes John, Worthington Jane, Barton Anne, Eyre Steve, Todd John A, Wallace Chris

Abstract excerpt

Determining whether potential causal variants for related diseases are shared can identify overlapping etiologies of multifactorial disorders. Colocalization methods disentangle shared and distinct causal variants. However, existing approaches require independent data sets. Here we extend two colocalization methods to allow for the shared-control design commonly used in comparison of genome-wide association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26053495
DOI: 10.1038/ng.3330
PMCID: PMC4754941

Genes

BCAR1
GLIS3
RNLS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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