Article

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

2019-03-28

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of genomic regions affecting complex diseases. The next challenge is to elucidate the causal genes and mechanisms involved. One approach is to use statistical colocalization to assess shared genetic aetiology across multiple related traits (e.g. molecular traits, metabolic pathways and complex diseases) to identify causal pathways, prioritize causal...

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Literature Corpus work: 60ee683c-5e1b-544e-bed1-0038ee794442
DOI: 10.1101/592238

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