Article
An Accurate Genetic Colocalisation Method for the HLA Locus.
HLA - 1 May 2026
Butler-Laporte Guillaume, Lu Tianyuan, Morris Sam, Zhang Wenmin, Band Gavin, Hamilton Fergus, Chong Amanda, Lin Kuang, Nanjala Ruth, Richards J Brent, Lee Mei-Hsuan, Yang Ling, Yao Pang, Li Liming, Chen Zhengming, Luo Yang, Millwood Iona Y, Walters Robin G, Mentzer Alexander J
Abstract excerpt
Genetic colocalisation analyses are frequently conducted to determine if causal signals at a genetic locus are shared between two phenotypes. However, colocalisation is rarely undertaken at the HLA locus, due to its complex linkage disequilibrium (LD) and high polymorphism density. This lack of genetic causal inference method limits our ability to translate HLA associations into therapeutic targets. Here we...
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