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Article

Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation.

PLoS genetics - 1 May 2026

Reales Guillermo, Pullin Jeffrey M, Manipur Ichcha, Vigorito Elena, Wallace Chris

Abstract excerpt

Colocalisation analysis integrates GWAS and molecular QTL datasets to identify candidate effector genes. Even with a wide range of molecular QTLs, 40% or more of GWAS loci remain unexplained, leaving a "colocalisation gap". We systematically characterised two large-scale eQTL colocalisation studies, to describe the determinants of this gap and ultimately inform the selection and design of eQTL studies to close...

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Identifiers

PMID: 42102166
DOI: 10.1371/journal.pgen.1012141
PMCID: PMC13186366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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