Article

A comprehensive analysis of humanized mouse models for the study of cancer immunotherapies

2025-09-09

Abstract excerpt

Humanized immune system (HIS) mouse models, generated by engrafting tumors and hematopoietic cells of human (Hu) origin into immunodeficient host mice, effectively recapitulate key aspects of the crosstalk between human immune cells and tumors. These models represent a valuable tool for the preclinical evaluation of immunotherapies. In this study, we provide a comprehensive comparison of two widely used HIS models...

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Literature Corpus work: 78fb2152-3fe1-511b-a6c5-052b1e14c543
DOI: 10.1101/2025.09.04.674233

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