Humanized patient-derived xenografts preserve tumour-specific immune microenvironments

Abstract excerpt

Defining the genetic and cellular programs that allow solid tumours to evade immune control requires preclinical models that preserve the complexity of the human tumour immune microenvironment. Most available systems capture only part of this biology. Organoid cultures and ex vivo tumour fragments can retain patient-derived tumour architecture and associated immune cells, but immune populations are typically main...

Topics

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• CD8-Positive T-Lymphocytes
• Cell Line, Tumor
• Disease Models, Animal
• Immunophenotyping
• Lymphocyte Activation
• Lymphocytes, Tumor-Infiltrating
• Neoplasms
• T-Lymphocyte Subsets

Identifiers and source

Literature Corpus work

607c1403-f75d-52e7-8c0f-8737f3d5304c

DOI

10.64898/2026.05.15.724697