Article

Immune humanized mice reconstituted with peripheral blood mononuclear cells or hematopoietic stem cells develop distinct MDA-MB-231 tumor immune microenvironments

2023-05-03

Abstract excerpt

Triple-negative breast cancer (TNBC) is one of the most fatal subtype of breast cancer. Tumor immune microenvironments (TIMEs) have critical influences on TNBC therapies. However, syngeneic mouse tumor models are insufficient to evaluate immunotherapeutic efficacy, because the different immune responses between mice and human. Therefore, human xenograft tumor mouse models with humanized immune systems (HIS) are mo...

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Literature Corpus work: 612af45a-8418-5a48-ab73-564e1f6de92f
DOI: 10.21203/rs.3.rs-2822769/v1

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Immune humanized mice reconstituted with peripheral blood mononuclear cells or hematopoietic stem cells develop distinct MDA-MB-231 tumor immune microenvironmentsDOI 10.21203/rs.3.rs-2822769/v1Read

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