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Article

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

2022-08-19

Abstract excerpt

Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by inter-species differences between human and mouse, as well as inter-person germline and somatic variation. Here we develop an autologous system that models the TME in individual patients. With patient-derived bone marrow, we engra...

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Identifiers and source

Literature Corpus work
41b43e61-f6eb-5fcc-b4b1-7fea385601ac
DOI
10.1101/2022.08.19.503502
Open publication

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Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironmentDOI 10.1101/2022.08.19.503502
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