Article

Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

2021-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Modeling the tumor-immune cell interactions in humanized mice is complex and limits drug development. Here, we generated easily accessible tumor models by transforming either primary skin fibroblasts or iPSC-derived cell lines injected in immune-deficient mice reconstituted with human autologous immune cells. Our results showed that either fibroblastic, hepatic or neural tumors were all efficien...

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Literature Corpus work: 4b4d8077-cc93-590b-a2d3-3e212aa9ba68
DOI: 10.1101/2021.04.02.437733

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