Article
Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes.
Frontiers in immunology - 1 Jan 2021
Marín-Jiménez Juan A, Capasso Anna, Lewis Matthew S, Bagby Stacey M, Hartman Sarah J, Shulman Jeremy, Navarro Natalie M, Yu Hui, Rivard Chris J, Wang Xiaoguang, Barkow Jessica C, Geng Degui, Kar Adwitiya, Yingst Ashley, Tufa Dejene M, Dolan James T, Blatchford Patrick J, Freed Brian M, Torres Raul M, Davila Eduardo, Slansky Jill E, Pelanda Roberta, Eckhardt S Gail, Messersmith Wells A, Diamond Jennifer R, Lieu Christopher H, Verneris Michael R, Wang Jing H, Kiseljak-Vassiliades Katja, Pitts Todd M, Lang Julie
Abstract excerpt
Over the past decade, immunotherapies have revolutionized the treatment of cancer. Although the success of immunotherapy is remarkable, it is still limited to a subset of patients. More than 1500 clinical trials are currently ongoing with a goal of improving the efficacy of immunotherapy through co-administration of other agents. Preclinical, small-animal models are strongly desired to increase the pace of...
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