Article
Modeling Infectious Diseases in Mice with a “Humanized” Immune System
6 Apr 2019
Abstract excerpt
ABSTRACT Human immune system (HIS) mice are created by transplanting human immune cells or their progenitor cells into highly immunodeficient recipient mouse hosts, thereby “humanizing” their immune systems. Over past decades, the field of HIS mice has evolved rapidly, as modifications of existing immunodeficient mouse strains have been developed, resulting in increasing levels of human tissue engraftment as...