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Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulation

2025-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME). To achieve more predictive preclinical insights, advanced in vivo models that faithfully recapitulate the human brain immune landscape are urgently needed. Here, we established GBM patient-derived orthotopic xenografts (PDO...

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Literature Corpus work
b01245ac-f515-54a8-84c6-91a4ccecbdcc
DOI
10.1101/2025.11.20.689484
Open publication

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Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulationDOI 10.1101/2025.11.20.689484
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