Article

Memory T Cells in MHC-Deficient Humanized Mice

2026-08-21

Abstract excerpt

Major histocompatibility complexes (MHC) govern antigen presentation and T cell receptor (TCR) selection. Accurate in vivo modeling of human immunity therefore requires physiological human MHC TCR interactions. Humanized NOD scid IL2null (NSG) mice engrafted with human CD34+ hematopoietic stem cells are widely used to provide preclinical platforms for the development of advanced therapies; however, interactions be...

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Literature Corpus work: a903f12a-c1a6-58bb-8394-90d3d9b69f40
DOI: 10.64898/2026.08.20.745695

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