Article

Role ofbaxMutations in Apoptosis in Colorectal Cancers With Microsatellite Instability

2005-04-01

Abstract excerpt

Half of colorectal tumors with microsatellite instability contain frameshift mutations in the (G)8 tract of bax, a major apoptosis effector, but their functional significance remains unclear. We studied the role of bax mutations on bax expression and apoptosis in 59 primary colorectal cancers of which 41 were microsatellite unstable. Tumors were screened for bax(G)8 mutations and evaluated immunohistochemically fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78ce3dc2-6503-50c6-bc09-4b2f3caeb856
DOI: 10.1309/jq2x3rv3l8f9tgyw

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Role ofbaxMutations in Apoptosis in Colorectal Cancers With Microsatellite InstabilityDOI 10.1309/jq2x3rv3l8f9tgywRead

Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability.Semantic proximity Read

Microsatellite instability is associated with the loss of apoptosis in ductal breast carcinomas.Semantic proximity Read

Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability.Semantic proximity Read

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.Semantic proximity Read

Mutational inactivation of the proapoptotic gene <i>BAX</i> confers selective advantage during tumor clonal evolutionSemantic proximity Read

Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues.Semantic proximity Read

Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability.Semantic proximity Read

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.Semantic proximity Read

Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAXSemantic proximity Read

Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas.Semantic proximity Read

Microsatellite instability and frameshift mutations in the Bax gene in hereditary nonpolyposis colorectal carcinoma.Semantic proximity Read

Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.Semantic proximity Read