Article
Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.
Cancer research - 1 Oct 1997
Yamamoto H, Sawai H, Perucho M
Abstract excerpt
An exacerbated genomic instability characterizes hereditary and sporadic gastrointestinal cancer of the microsatellite mutator phenotype (MMP), generating somatic frameshift mutations in genes containing mononucleotide repeats. We have recently shown that approximately 50, 40, and 30% of MMP+ col...
Topics
- Apoptosis
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA Probes
- DNA Repair
- DNA, Neoplasm
- Frameshift Mutation
- Genes, Tumor Suppressor
- Humans
- Microsatellite Repeats
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Stomach Neoplasms
- bcl-2-Associated X Protein