Article
Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability.
American journal of clinical pathology - 1 Apr 2005
Miquel Catherine, Borrini Francesco, Grandjouan Sophie, Aupérin Anne, Viguier Jérôme, Velasco Valérie, Duvillard Pierre, Praz Françoise, Sabourin Jean-Christophe
Abstract excerpt
Half of colorectal tumors with microsatellite instability contain frameshift mutations in the (G)8 tract of bax, a major apoptosis effector, but their functional significance remains unclear. We studied the role of bax mutations on bax expression and apoptosis in 59 primary colorectal cancers of which 41 were microsatellite unstable. Tumors were screened for bax(G)8 mutations and evaluated immunohistochemically...
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