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Article

Mutational inactivation of the proapoptotic gene <i>BAX</i> confers selective advantage during tumor clonal evolution

12 Sept 2000

Abstract excerpt

A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene family underlie the MMP, a landmark for hereditary nonpolyposis colorectal cancer. These tumors define a distinctive pathway for carcinogenesis because they display a particular spectrum of mutated cancer genes containing target...

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PMID: 10984511
DOI: 10.1073/pnas.190210897

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