Article
Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues.
Histochemistry and cell biology - 1 Jul 2020
Mañas Adriana, Yao Qi, Davis Aislinn, Basheer Sana, Beatty Evan, Zhang Honghong, Li Jiajun, Nelson Adam, Zhang Huaiyuan, Xiang Jialing
Abstract excerpt
The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the reading frame is restored allowing production of a full-length protein (Bax∆2). Unlike the parental Baxα, Bax∆2 triggers apoptosis through a non-mitochondrial pathway and...
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