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Article

Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas.

Gastroenterology - 1 Feb 1998

Yagi O K, Akiyama Y, Nomizu T, Iwama T, Endo M, Yuasa Y

Abstract excerpt

BACKGROUND & AIMS: The p53 and BAX genes have been linked to apoptosis. p53 was not frequently found to be mutated in colorectal carcinomas with a microsatellite mutator phenotype, but frame-shift mutations in a tract of eight guanines within BAX were frequently found in these carcinomas. To understand the roles of these genes in hereditary nonpolyposis colorectal cancer (HNPCC) tumorigenesis, we examined whether...

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Source

Identifiers

PMID: 9453486
DOI: 10.1016/s0016-5085(98)70477-9

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas.PMID 9453486Read ↗

Microsatellite instability and frameshift mutations in the Bax gene in hereditary nonpolyposis colorectal carcinoma.Semantic proximity Read ↗

Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability.Semantic proximity Read ↗

Role ofbaxMutations in Apoptosis in Colorectal Cancers With Microsatellite InstabilitySemantic proximity Read ↗

Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.Semantic proximity Read ↗

Mutational inactivation of the proapoptotic gene <i>BAX</i> confers selective advantage during tumor clonal evolutionSemantic proximity Read ↗

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.Semantic proximity Read ↗

Microsatellite instability in Japanese hereditary non-polyposis colorectal cancer does not induce mutation of a simple repeat sequence of the bax gene.Semantic proximity Read ↗

Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype.Semantic proximity Read ↗

Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability.Semantic proximity Read ↗

Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype.Semantic proximity Read ↗

Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent PathwaysSemantic proximity Read ↗

Immunohistochemical detection of the pro-apoptotic Bax∆2 protein in human tissues.Semantic proximity Read ↗

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