Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.

doi:10.1038/sj.onc.1202109

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Article

Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.

Oncogene - 15 Oct 1998

Simms L A, Radford-Smith G, Biden K G, Buttenshaw R, Cummings M, Jass J R, Young J, Meltzer S J, Leggett B A

Abstract excerpt

Though most colorectal cancers show allelic losses, a subset of colorectal cancers (microsatellite instability or MSI-positive cancers) develop numerous small insertion and deletion mutations in repetitive DNA. Some of these sequences occur in coding regions of cancer related genes which, when ta...

Topics

Amino Acid Sequence
Base Sequence
Colorectal Neoplasms
Genes, p53
Humans
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
bcl-2-Associated X Protein

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