Article
Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers.
Oncogene - 15 Oct 1998
Simms L A, Radford-Smith G, Biden K G, Buttenshaw R, Cummings M, Jass J R, Young J, Meltzer S J, Leggett B A
Abstract excerpt
Though most colorectal cancers show allelic losses, a subset of colorectal cancers (microsatellite instability or MSI-positive cancers) develop numerous small insertion and deletion mutations in repetitive DNA. Some of these sequences occur in coding regions of cancer related genes which, when targeted by frameshift mutations, produce truncations in their protein product. Such a gene is the proapoptotic tumor...
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