Article

A Statistical Framework to Identify Cell Types Whose Genetically Regulated Proportions are Associated with Complex Diseases

2021-03-01

Abstract excerpt

<h4>Finding: </h4> disease-relevant tissues and cell types can facilitate the identification and investigation of functional genes and variants. In particular, cell type proportions can serve as potential disease predictive biomarkers. Here, we introduce a novel statistical framework, cell-type Wide Association Study (cWAS), that integrates genetic data with transcriptomics data to identify cell types whose geneti...

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Literature Corpus work: 03840628-d6dd-5d6e-8397-59e5f9701076
DOI: 10.1101/2021.02.25.21252462

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