Article

Quantifying genetic effects on disease mediated by assayed gene expression levels

2019-08-09

Abstract excerpt

Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs). However, it remains unclear whether this overlap is driven by mediation of genetic effects on disease by expression levels, or whether it primarily reflects pleiotropic relationships instead. Here we introduce a new method, mediated expression score regression (MESC), to estimate d...

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Literature Corpus work: 2cd141aa-0b50-512c-ac74-d8800f6a0ba3
DOI: 10.1101/730549

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