Article

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

2016-03-23

Abstract excerpt

Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We apply this framework to 44 GTEx tissues and 100+ phenotypes from GWAS and meta-analysis studies, c...

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Literature Corpus work: eba1a684-6430-5782-a3a3-266ec1851a3e
DOI: 10.1101/045260

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