Article
Genetically regulated gene expression and proteins revealed discordant effects.
PloS one - 1 Jan 2022
Pott Janne, Garcia Tarcyane, Hauck Stefanie M, Petrera Agnese, Wirkner Kerstin, Loeffler Markus, Kirsten Holger, Peters Annette, Scholz Markus
Abstract excerpt
BACKGROUND: Although gene-expression (GE) and protein levels are typically strongly genetically regulated, their correlation is known to be low. Here we investigate this phenomenon by focusing on the genetic background of this correlation in order to understand the similarities and differences in the genetic regulation of these omics layers. METHODS AND RESULTS: We performed locus-wide association studies of 92...
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