AGS3-based optogenetic GDI induces GPCR-independent Gβγ signaling and macrophage migration

Abstract excerpt

G protein-coupled receptors (GPCRs) are efficient Guanine nucleotide exchange factors (GEFs) and exchange GDP to GTP on the Gα subunit of G protein heterotrimers in response to various extracellular stimuli, including neurotransmitters and light. GPCRs primarily broadcast signals through activated G proteins, GαGTP, and free Gβγ and are major disease drivers. Evidence shows that the ambient low threshold signaling...

Topics

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• Amino Acid Motifs
• Biosensing Techniques
• GTP-Binding Protein alpha Subunits, Gq-G11
• Guanine Nucleotide Exchange Factors
• Guanosine Triphosphate
• Heterotrimeric GTP-Binding Proteins
• Receptors, G-Protein-Coupled
• Urinary Bladder Neoplasms

Identifiers and source

Literature Corpus work

78943e82-b086-5c48-8a40-124ca0823dc1

DOI

10.1101/2024.06.04.597473