Spatiotemporal optical control of Gαq-PLCβ interactions

Abstract excerpt

Cells experience time-varying and spatially heterogeneous chemokine signals in vivo, activating cell surface proteins, including G protein-coupled receptors (GPCRs). The Gαq pathway activation by GPCRs is a major signaling axis with a broad physiological and pathological significance. Compared to other Gα members, GαqGTP activates many crucial effectors, including PLCβ (Phospholipase Cβ) and Rho GEFs (Rho guanine...

Topics

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• Amino Acid Motifs
• Biosensing Techniques
• GTP-Binding Protein alpha Subunits, Gq-G11
• Guanine Nucleotide Exchange Factors
• Guanosine Triphosphate
• Heterotrimeric GTP-Binding Proteins
• Receptors, G-Protein-Coupled
• Urinary Bladder Neoplasms

Identifiers and source

Literature Corpus work

eeb67ab6-5238-5567-bc1f-d208b9f57ec9

DOI

10.1101/2023.08.10.552801