Quantitative live-cell imaging of GPCR downstream signaling dynamics

Abstract excerpt

G-protein-coupled receptors (GPCRs) play an important role in sensing various extracellular stimuli, such as neurotransmitters, hormones, and tastants, and transducing the input information into the cell. While the human genome encodes more than 800 GPCR genes, only four Gα-proteins (Gα s , Gα i/o , Gα q/11 , and Gα 12/13 ) are known to couple with GPCRs. It remains unclear how such divergent GPCR information...

Topics

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• Amino Acid Motifs
• Biosensing Techniques
• GTP-Binding Protein alpha Subunits, Gq-G11
• Guanine Nucleotide Exchange Factors
• Guanosine Triphosphate
• Heterotrimeric GTP-Binding Proteins
• Receptors, G-Protein-Coupled
• Urinary Bladder Neoplasms

Identifiers and source

Literature Corpus work

70096661-5003-5471-9ebe-0695a5816726

DOI

10.1101/2021.08.22.457285