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Article

Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling.

Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2012

Garcia-Marcos Mikel, Kietrsunthorn Patrick S, Pavlova Yelena, Adia Michelle A, Ghosh Pradipta, Farquhar Marilyn G

Abstract excerpt

Heterotrimeric G proteins are critical signal-transducing molecules controlled by a complex network of regulators. GIV (a.k.a. Girdin) is a unique component of this network and a nonreceptor guanine nucleotide exchange factor (GEF) that functions via a signature motif. GIV's GEF motif is involved in the regulation of critical biological processes such as phosphoinositide 3 kinase (PI3K)-Akt signaling, actin...

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Identifiers

PMID: 22308453
DOI: 10.1073/pnas.1120538109
PMCID: PMC3277514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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