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Article

Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells.

The Journal of biological chemistry - 11 May 2018

Wan Qingwen, Okashah Najeah, Inoue Asuka, Nehmé Rony, Carpenter Byron, Tate Christopher G, Lambert Nevin A

Abstract excerpt

G protein-coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signaling. Here, we show that mini G proteins are robust probes that can be used in a variety of assay formats to report GPCR activity in living cells. Mini G (mG) proteins...

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Identifiers

PMID: 29523687
DOI: 10.1074/jbc.RA118.001975
PMCID: PMC5949987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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