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Article

Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditions.

International journal of biological macromolecules - 1 Apr 2026

Marino Valerio, Ahoulou Effibe O, Dal Cortivo Giuditta, Avesani Anna, Ames James B, Dell'Orco Daniele

Abstract excerpt

Guanylate Cyclase Activating Protein 1 (GCAP1) and Retinal Degeneration Protein 3 (RD3) are key regulators of retinal guanylate cyclase 1 (GC1), whose dysregulation leads to inherited retinal dystrophies (IRDs). While GCAP1 mutations cause constitutive GC1 activation and photoreceptor degeneration, RD3 acts as a potent cyclase inhibitor essential for proper GC1 trafficking. Here, we investigated the molecular...

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Identifiers

PMID: 41819313
DOI: 10.1016/j.ijbiomac.2026.151333

Genes

RD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditions.PMID 41819313Read ↗

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