Article
A Universal Allosteric Mechanism for G Protein Activation
2020-11-16
Abstract excerpt
<h4>SUMMARY</h4> G proteins play a central role in signal transduction and pharmacology. Signaling is initiated by cell-surface receptors, which promote GTP binding and the dissociation of Gα from the Gβγ subunits. Structural studies have revealed the molecular basis for subunit association with receptors, RGS proteins and downstream effectors. In contrast, the mechanism of subunit dissociation is poorly understo...
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Identifiers and source
- Literature Corpus work
- 3228fd4f-0c92-5daf-a2f7-46161669e1be
- DOI
- 10.1101/2020.11.15.383679