Article

Programmable genetic control of tumor-colonizing Bifidobacterium longum for intratumoral therapeutic delivery and biocontainment

2026-08-13

Abstract excerpt

Engineered bacteria offer a distinct modality for cancer therapy by exploiting the ability of certain species to colonize tumors and deliver therapeutic payloads. Improving their efficacy and safety requires control over bacterial activity after tumor colonization, yet few microbial chassis permit it. Bifidobacterium longum, a probiotic with intrinsic tumor-targeting and antitumor activity, is a promising chassis...

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Literature Corpus work: 7884ac52-4d1c-52d6-a60e-2b99f27bf543
DOI: 10.64898/2026.08.12.744520

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