Article

Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc, a key driver of tumourigenesis.

2023-09-01

Abstract excerpt

<title>Abstract</title> <p><bold>BACKGROUND</bold>: Bacterial cancer therapy was first trialled in patients at the end of the nineteenth century. More recently, tumour-targeting bacteria have been harnessed to deliver plasmid-expressed therapeutic interfering RNA to a range of solid tumours. A major limitation to clinical translation of this is the short-term nature of RNA interference in vivo due to plasmid inst...

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Literature Corpus work: 1e690894-f617-59c4-af93-5f22eec7bcd6
DOI: 10.21203/rs.3.rs-3262697/v1

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