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Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

2019-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Immunotherapies such as checkpoint inhibitors have revolutionized cancer therapy yet lead to a multitude of immune-related adverse events, suggesting the need for more targeted delivery systems. Due to their preferential colonization of tumors and advances in engineering capabilities from synthetic biology, microbes are a natural platform for the local delivery of cancer therapeutics. Here, we p...

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Literature Corpus work
f7d7cd9a-eb92-5636-8014-db1fea0baf4f
DOI
10.1101/562785
Open publication

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