Article
Engineered bacteria detect tumor DNA.
Science (New York, N.Y.) - 11 Aug 2023
Cooper Robert M, Wright Josephine A, Ng Jia Q, Goyne Jarrad M, Suzuki Nobumi, Lee Young K, Ichinose Mari, Radford Georgette, Ryan Feargal J, Kumar Shalni, Thomas Elaine M, Vrbanac Laura, Knight Rob, Woods Susan L, Worthley Daniel L, Hasty Jeff
Abstract excerpt
Synthetic biology has developed sophisticated cellular biosensors to detect and respond to human disease. However, biosensors have not yet been engineered to detect specific extracellular DNA sequences and mutations. Here, we engineered naturally competent Acinetobacter baylyi to detect donor DNA from the genomes of colorectal cancer (CRC) cells, organoids, and tumors. We characterized the functionality of the...
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