Article

Global early replication disrupts gene expression and chromatin conformation in a single cell cycle

2022-05-11

Abstract excerpt

The early embryonic divisions of many organisms, including fish, flies and frogs are characterised by a very rapid S-phase caused by high rates of replication initiation. In somatic cells, S-phase is much longer due to both a reduction in the total number of initiation events and the imposition of a temporal order of origin activation. The physiological importance of changes in the rate and timing of replication i...

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Literature Corpus work: 400f0f15-db7b-5513-b538-b4d0a59961ff
DOI: 10.1101/2022.05.11.491470

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