Article

Ngfr suppresses Lcn2/Slc22a17 signaling, induces neurogenesis and reduces amyloid pathology in the hippocampus of APP/PS1dE9 mouse

2022-08-21

Abstract excerpt

Neurogenesis relates to the brain resilience and is reduced in Alzheimer’s disease (AD). Restoring healthy levels of neurogenesis could have beneficial effects for coping with neurodegeneration. However, molecular mechanisms that could enhance neurogenesis from astroglial progenitors in AD pathology are largely unknown. We used lentiviruses to express Ngfr in the hippocampus of the APP/PS1dE9 mouse model of AD, h...

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Literature Corpus work: 7843ee91-0d92-54a1-bb5f-019a42af8d02
DOI: 10.1101/2022.08.20.504608

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Ngfr suppresses Lcn2/Slc22a17 signaling, induces neurogenesis and reduces amyloid pathology in the hippocampus of APP/PS1dE9 mouseDOI 10.1101/2022.08.20.504608Read

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