Article
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
The Journal of clinical investigation - 15 Mar 2023
Marsan Elise, Velmeshev Dmitry, Ramsey Arren, Patel Ravi K, Zhang Jiasheng, Koontz Mark, Andrews Madeline G, de Majo Martina, Mora Cristina, Blumenfeld Jessica, Li Alissa N, Spina Salvatore, Grinberg Lea T, Seeley William W, Miller Bruce L, Ullian Erik M, Krummel Matthew F, Kriegstein Arnold R, Huang Eric J
Abstract excerpt
Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in the thalamocortical circuit in Grn-/- mice, the exact mechanism for neurodegeneration in FTLD-GRN remains unclear. By performing comparative single-cell transcriptomics in the thalamus and...
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